Can Pharmacometabolomics and LC-HRMS develop a new Concept for Therapeutic Drug Monitoring?


The discoveries and insights made using pharmacometabolomics and high-resolution mass spectrometry, and the tradition of TDM to precisely quantify the target drug and/or metabolites can form a fundament for developing TDM further. The scientific knowledge that genetics and environmental factors play a role must be taken into account and be explored. There may be several ways to do this (26) but one way could be to further develop the concept of TDM in order to better meet the trend towards a more specific and personalized drug therapy.

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