Development and Validation of a Stability-Indicating Method for Bone Morphogenetic Protein-2

Bone morphogenetic protein-2 (BMP-2) is an osteoinductive and osteointegrating signaling molecule. It is secreted in the human body as a glycoprotein and the molecular weight of its dimer isoforms are between 26-30kDa. It belongs to the Transforming Growth Factor-β family of cytokines which are critical in cellular formation and differentiation, predominantly during the embryonic stages. Recombinant BMP-2 in the past decade has largely been cloned in Chinese Hamster Ovary (CHO) cell lines. When applied as a formulation with a biodegradable scaffold at the trauma site, it helps in bone regeneration and healing.

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