Investigation of Potential in vivo Cleavage of Biotherapeutic Protein by Immunocapture-LC/MS

In recent years, there has been increasing demand to understand in vivo biotransformation of biotherapeutics and its impact on pharmacokinetics, efficacy, immunogenicity and safety. Liquid chromatography/mass spectrometry has been the primary technology for such investigation. In this study, a biotherapeutic protein was investigated for potential linker cleavage or truncation in vivo following intravenous administration to monkeys..

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