In recent years, there has been increasing demand to understand in vivo biotransformation of biotherapeutics and its impact on pharmacokinetics, efficacy, immunogenicity and safety. Liquid chromatography/mass spectrometry has been the primary technology for such investigation. In this study, a biotherapeutic protein was investigated for potential linker cleavage or truncation in vivo following intravenous administration to monkeys..
Click to rate this post!
[Total: 1 Average: 5]