Microbial products continue to represent one of the most interesting sources for the discovery and development of novel drugs. As a result of the massive screening of microbes since 1950, one of the most important hindrances encountered so far in screening microbial natural products is reisolation of already discovered bioactive molecules. Thus, identifying known or undesirable compounds from natural product extracts at an early stage, indicated here as chemical dereplication, is a key step in the process, saving resources and speeding up the discovery process of novel drugs. In this mini-review, we highlight the analytical techniques commonly used to evaluate the novelty of microbial metabolites during screening and the advances that have been made in related technologies.
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